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Cellular and tissue restoration in plants is a unique process.  Differing from stem cells of animals and of humans, those of plants contain properties that stimulate regeneration and growth after injury.  

Plant mechanism for regeneration of tissues under stress:  In recent years, significant resources have been invested into research of this mechanism which has contributed to an expansion of the field of plant biotechnology.

According to L Xu, H Huang (1), studies of plant regeneration are of high significance given the underlying potential of applying plant regeneration mechanisms for commercial and industry use as in skin care cosmetics.

Research consistently demonstrates the positive effects of plant stem cell-based skin treatment. Skin care products based on plants (marine) have proved to be beneficial to mention trendy, innovative and safe.

Clinical trial of Malus Domestica (Photocell Tech), a liposome encapsulated extract of plant marine stem cell as a cosmetic ingredient has shown significant potential to reduce wrinkles in the crow’s feet area of the face (11) Depth of the wrinkles are measured with specialized optical measurement technologies that showed shallower wrinkles by 8% after 2-weeks and by 15% after 4 weeks.

Ancient herbal science such as Ayurveda and Chinese medicine have used plant and herbal remedies as the main stay of treatment of chronic ailments, for acute inflammation and for healing. Our research and development concentrates on improving the method and catalyst with which plant and herbal extract formulas are delivered to the skin in new, innovative, effective and targeted ways.



Papers of special note have been highlighted as: • of interest; •• of considerable interest

  1. Xu L, Huang H. Genetic and epigenetic controls of plant regeneration. Curr. Top. Dev. Biol. 2014;108:1–33. [PubMed] [Google Scholar]• Understanding gene-level regeneration pathways in plants.
  2. Su YH, Zhang XS. The hormonal control of regeneration in plants. Curr. Top. Dev. Biol. 2014;108:35–69. [PubMed] [Google Scholar]•• Plant phytohormone cascades involved in plant stress management.
  3. Blanpain C, Fuchs E. Epidermal stem cells of the skin. Annu. Rev. Cell Dev. Biol. 2006;22:339–373. [PMC free article] [PubMed] [Google Scholar]
  4. Shen Q, Jin H, Wang X. Epidermal stem cells and their epigenetic regulation. Int. J. Mol. Sci. 2013;14(9):17861–17880. [PMC free article] [PubMed] [Google Scholar]
  5. Byrne ME, Kidner CA, Martienssen RA. Plant stem cells: divergent pathways and common themes in shoots and roots. Curr. Opin. Genet. Dev. 2003;13(5):551–557. [PubMed] [Google Scholar]
  6. Fehér A. Somatic embryogenesis — stress-induced remodeling of plant cell fate. Biochim. Biophys. Acta. 2015;1849(4):385–402. [PubMed] [Google Scholar]•• Plant embryogenesis and understanding the most primitive plant stem cells.
  7. Watson JM, Riha K. Comparative biology of telomeres: where plants stand. FEBS Lett. 2010;584(17):3752–3759. [PMC free article] [PubMed] [Google Scholar]•• Relation of telomeres to aging cells/tissue.
  8. Sablowski R. Plant & animal stem cells: conceptually similar, molecularly distinct? Trends Cell Biol. 2004;14(11):605–611. [PubMed] [Google Scholar]
  9. Singh G. Plant Cell and Tissue Culture for the Production of Food Ingredients. Springer Science & Business Media; NY, USA: 1999. Elicitation—manipulating and enhancing secondary metabolite production; pp. 101–111. [Google Scholar]
  10. Morus M, Baran M, Rost-Roszkowska M, Skotnicka-Graca U. Plant stem cells as innovation in cosmetics. Acta Pol. Pharm. 2014;71(5):701–707. [PubMed] [Google Scholar]
  11. Schmid D, Schürch C, Blum P, Belser E, Züll F. Plant stem cell extract for longevity of skin and hair. SÖFW J. 2008;134(5):30–35. [Google Scholar]•• Connection of plant stem cells to skin and hair evidence-based literature.
  12. Nohynek L, Bailey M, Tähtiharju J, et al. Cloudberry (Rubus chamaemorus) cell culture with bioactive substances: establishment and mass propagation for industrial use. Engineer. Life Sci. 2014;14(6):667–675. [Google Scholar]
  13. Barbulova A, Apone F, Colucci G. Plant cell cultures as source of cosmetic active ingredients. Cosmetics. 2014;1(2):94–104. [Google Scholar]
  14. Tito A, Carola A, Bimonte M, et al. A tomato stem cell extract containing antioxidant compounds and metal chelating factors protects skin cells from heavy metal-induced damages. Int. J. Cosmet. Sci. 2011;33(6):543–552. [PubMed] [Google Scholar]
  15. Naolys: Refine ginger restores skin texture.
  16. Gracioso O, Ringenbach C, Doridot E, Mondon P. 2016. WO 2016113659 A1.
  17. Specialchem. Sederma launches Citystem™ to fight pollution damage
  18. Backman J, Isohanni T, Oksman-Caldentey KM, Nohynek L, Rischer H, Puupponen-Pimiä R. 2014. WO2013124540.
  19. Worldhealth. Stem cells in skin care. What does it really mean?
    •• Gives a current understanding and adds to the purpose of the article.
  20. Make{me}heal. XTEMcell Stem Cell SkinCare.
  21. Image Skincare. Stem cells.
  22. Beri K, Milgraum SS. Neocollagenesis in deep and superficial dermis by combining fractionated Q-switched ND: YAG 1,064-nm with topical plant stem cell extract and N-acetyl glucosamine: open case series. J. Drugs Dermatol. 2015;14(11):1342. [PubMed] [Google Scholar]•• Future dimensions of plant stem cells in cosmetics.